Paper Title
Host Responses in Peri-Implant Tissue in Comparison to Periodontal Tissue
Abstract
The host response in peri-implant tissue may differ from that in periodontal tissue in a healthy individual. The
purpose of this study is to investigate the expression of inflammatory cytokines in peri-implant crevicular fluid (PICF) from
single implant with different abutment types in comparison to healthy periodontal tissue.
Nineteen participants with healthy implants and teeth were recruited according to inclusion and exclusion criteria. PICF and
gingival crevicular fluid (GCF) was collected using sterile paper points. The expression level of inflammatory cytokines
including IL-1α, IL-1β, TNF-α, IFN-γ, IL-6, and IL-8 was assessed using enzyme-linked immunosorbent assay (ELISA).
Paired t test was used to compare the expression levels of inflammatory cytokines around natural teeth and peri-implant in
PICF and GCF of the same individual. The Independent t test was used to compare the expression levels of inflammatory
cytokines in PICF from titanium and UCLA abutment.
Expression of IL-6, TNF-α, and IFN-γ in PICF was not statistically different from GCF among titanium and UCLA
abutment group. However, the level of IL-1α in the PICF from the implants with UCLA abutment was significantly higher
than GCF (P=0.030). In addition, the level of IL-1β in PICF from the implants with titanium abutment was significantly
higher than GCF (P=0.032). When different abutment types was compared, IL-8 expression in PICF from implants with
UCLA abutment was significantly higher than titanium abutment (P=0.003).
Keywords- Abutment, Dental implant, Gingivalcrevicular fluid and Peri-implant crevicular fluid